Add flour, salt, yeast and pumpkin seeds to a large bowl. Whisk together until combined.
Add water to the flour mixture and stir until a thick dough forms. It will be a little scrappy and sticky. Cover the bowl with plastic wrap and let rest at room temperature overnight.
When ready to bake, preheat oven to 450 degrees. Place a large 6 QT enamel Dutch oven in the oven for 30 minutes to heat it up.
Remove dough from the bowl and add to a well-floured, clean work surface. Shape the dough into a ball and coat lightly in flour. Cover with a sheet of plastic wrap until your Dutch oven is hot.
Remove plastic from dough. Add dough to a piece of parchment paper big enough to line the Dutch oven. Add parchment paper with dough to the hot pan carefully.
Bake for 30 minutes uncovered. Remove from oven once golden brown and crispy on top.
Serve warm.