Combine tequila and peppers in an airtight container. Allow the tequila to infuse for at least 5 to 8 hours (or more if you want it H-O-T).
When ready to make the margarita, stir together ingredients for chili salt in a small bowl. Rub a margarita or cocktail glass with the lime wedge, then rim with chili salt.
In a shaker filled with ice, combine chile infused tequila, lime juice, orange liqueur and agave. Shake vigorously.
Fill rimmed glass with ice. Strain margarita into the glass and serve.
notes
To make this cocktail for 8 people, use all of the infused tequila (1 1/2 cups), 1/2 cup lime juice, 1 cup orange liqueur, and 3/4 cup agave. Assemble in a pitcher, stirring vigorously with ice to combine!